反应详情

To a solution of crude 4-benzyl-2-phthalimidomethylmorpholine (64 g) in ethanol (500 ml) was added hydrazine monohydrate (18 ml, 0.57 mol) and the mixture was heated under reflux for 2 hours. After cooling, 10% aqueous sodium hydroxide (200 ml) was added to dissolve insolubles and the ethanol was distilled off under reduced pressure. The aqueous layer was extracted with chloroform (200 ml×3), the combined organic layer was dried over potassium carbonate and the solvent was distilled off to give crude 2-aminomethyl-4-benzylmorpholine (42.97 g). This compound was used for the subsequent reaction without purification.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hours
3. temperatureAfter cooling
4. dissolutionto dissolve insolubles
5. distillationthe ethanol was distilled off under reduced pressure
6. extractionThe aqueous layer was extracted with chloroform (200 ml×3)
7. dry with materialthe combined organic layer was dried over potassium carbonate
8. distillationthe solvent was distilled off