Methyl Isocyanate → 5-Cyano-3-methyl-6-methylthio-1-phenyl-2,4(1H,3H)-pyrimidinedione

HRID 1598387Notes

Reaction equation

HRID 1598387 reaction equation
[C:1]([C:3](=[C:9]([S:17][CH3:18])[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:4]([O:6]CC)=O)#[N:2].[CH3:19][N:20]=[C:21]=[O:22]>>[C:1]([C:3]1[C:4](=[O:6])[N:20]([CH3:19])[C:21](=[O:22])[N:10]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:9]=1[S:17][CH3:18])#[N:2]

Participants

3

Reactant 2

HCID 12228Methyl IsocyanateHCID 4200299Ethyl 3-anilino-2-cyano-3-methylsulfanylprop-2-enoate

Product 1

HCID 189334525-Cyano-3-methyl-6-methylthio-1-phenyl-2,4(1H,3H)-pyrimidinedioneYield 27%

Procedure

This compound was synthesized from ethyl 2-cyano-3-methylthio-3-phenylaminoacrylate and methyl isocyanate according to the same process as described in Example 92b. Yield=27%.

Sources & evidence

ORD record
ord-e2c1daaeb9d6451384ae9c2525971d3e
Source dataset
uspto-grants-1998_04
Patent number
US05736550

Reaction notes

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