(S)-tert-Butyl 2,4-dibenzylpiperazine-1-carboxylate → 1,1-Dimethylethyl (2S)-2-(phenylmethyl)-1-piperazinecarboxylate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 2, Step C, except using 1-tert-butoxycarbonyl-2(S),4-dibenzylpiperazine (4.78 g, 11.3 mmol) and 10% palladium on carbon (1.04 g). The title compound was obtained as an oil. NMR (300 MHz, CD3OD) δ 7.25 (5H, m), 4.35 (1H, m), 4.00 (1H, d, J=12 Hz), 2.7-3.3 (7H, m), 1.25 (9H, s).

Provenance & Evidence