HCID 67629372, compound → HCID 54397865, compound

HRID 1598455Notes

Reaction equation

HRID 1598455 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:23])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:16]=2[CH3:22])[C@@H:10]([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[Pd]>[CH2:24]([C@H:10]1[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[C:14](=[O:23])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:16]=1[CH3:22])[CH2:25][CH2:26][CH3:27]

Participants

5

Reactant 1

HCID 67629372HCID 67629372, compound

Product 1

HCID 54397865HCID 54397865, compoundYield 116.9%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

4-Benzyl-2(S)-n-butyl-1-(2,3-dimethylbenzoyl)piperazine (0.93 g, 2.55 mmol) was dissolved in methanol and hydrogenated in a Parr apparatus under 60 psi hydrogen in the presence of 10% Pd/C (0.186 g) for 24 h. The catalyst was removed by filtration through Celite, and the solvent removed in vacuo to obtain the title compound (0.818 g).

Workup

  1. customThe catalyst was removed by filtration through Celite
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-16f7895bbd46450da331111ad777e377
Source dataset
uspto-grants-1998_04
Patent number
US05736539

Reaction notes

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