Potassium bisulfate → HCID 22884155, compound

HRID 1598474Notes

Reaction equation

HRID 1598474 reaction equation
CON(C)[C:4](=[O:18])[C@H:5]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6][CH2:7][CH2:8][CH3:9].[H-].[Al+3].[Li+].[H-].[H-].[H-].S([O-])(O)(=O)=O.[K+]>CCOCC>[C:14]([O:13][C:11]([NH:10][C@H:5]([CH2:6][CH2:7][CH2:8][CH3:9])[CH:4]=[O:18])=[O:12])([CH3:17])([CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 516920Potassium bisulfateHCID 21226445Aluminium lithium hydrideHCID 22884176HCID 22884176, compound

Product 1

HCID 22884155HCID 22884155, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound was prepareded according to the procedure described in Example 1, Step C, except using N-methoxy-N-methyl 2(R)-tert-butoxycarbonylaminohexanamide (4.08 g, 14.89 mmol), lithium aluminum hydride (0.621 g, 16.37 mmol), in ether (200 mL), followed by potassium hydrogen sulfate (4.05 g, 29.78 mmol) workup. The title compound was obtained as a clear oil, 3.28 g. NMR (CDCl3, 300 MHz) δ 9.6 (1H, s), 5.04 (1H, bs), 4.23 (1H, m), 1.15-2.0 (15H, m), 0.9 (3H, m).

Sources & evidence

ORD record
ord-28b951c59bd445f9a98cd15c593a092b
Source dataset
uspto-grants-1998_04
Patent number
US05736539

Reaction notes

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