1-Benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate → 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate

HRID 1598485Notes

Reaction equation

HRID 1598485 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH:12]1[C:24]([O:26][CH3:27])=[O:25])=O)C1C=CC=CC=1>CO.[Pd]>[C:20]([O:19][C:17]([N:14]1[CH2:15][CH2:16][NH:11][CH:12]([C:24]([O:26][CH3:27])=[O:25])[CH2:13]1)=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

4

Reactant 1

HCID 44519651-Benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate

Product 1

HCID 27568191-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of the product from step A in methanol was hydrogenated at 60 psi in the presence of 10% Pd/C (0.250 g) for 24h. The catalyst was filtered and the methanol evaporated to yield the title compound as an oil (0.91 g).

Workup

  1. filtrationThe catalyst was filtered
  2. customthe methanol evaporated

Sources & evidence

ORD record
ord-c1c799a041a9478e925a1801265ae039
Source dataset
uspto-grants-1998_04
Patent number
US05736539

Reaction notes

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