Hydrogen Bromide → HCID 54710164, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,3-dihydro-6-ethoxycarbonyl-7-hydroxy-5-oxo-5H-pyrido[1,2,3-de]-1,4-benzoxazine (0.28 g) and hydrobromic acid (47%; 0.44 ml) in acetic acid (1.5 ml) was stirred at 75° C. for 1 hour. The mixture was cooled in ice-water. The precipitates were collected, washed with water, and dried in vacuo at 60° C. to give pale brown crystals of 2,3-dihydro-6-carboxy-7-hydroxy-5-oxo-5H-pyrido[1,2,3-de]-1,4-benzoxazine (0.19 g).

Provenance & Evidence