Hydrogen Bromide → HCID 54710164, compound

HRID 1598543Notes

Reaction equation

HRID 1598543 reaction equation
C([O:3][C:4]([C:6]1[C:18](=[O:19])[N:14]2[CH2:15][CH2:16][O:17][C:12]3[C:13]2=[C:8]([CH:9]=[CH:10][CH:11]=3)[C:7]=1[OH:20])=[O:5])C.Br>C(O)(=O)C>[C:4]([C:6]1[C:18](=[O:19])[N:14]2[CH2:15][CH2:16][O:17][C:12]3[C:13]2=[C:8]([CH:9]=[CH:10][CH:11]=3)[C:7]=1[OH:20])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 54710203HCID 54710203, compound

Product 1

HCID 54710164HCID 54710164, compoundYield 75.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
75 °C

Procedure

A mixture of 2,3-dihydro-6-ethoxycarbonyl-7-hydroxy-5-oxo-5H-pyrido[1,2,3-de]-1,4-benzoxazine (0.28 g) and hydrobromic acid (47%; 0.44 ml) in acetic acid (1.5 ml) was stirred at 75° C. for 1 hour. The mixture was cooled in ice-water. The precipitates were collected, washed with water, and dried in vacuo at 60° C. to give pale brown crystals of 2,3-dihydro-6-carboxy-7-hydroxy-5-oxo-5H-pyrido[1,2,3-de]-1,4-benzoxazine (0.19 g).

Workup

  1. customThe precipitates were collected
  2. washwashed with water
  3. customdried in vacuo at 60° C.

Sources & evidence

ORD record
ord-eebcaa2dee474df7a28908ba1dfa4abd
Source dataset
uspto-grants-1998_04
Patent number
US05739130

Reaction notes

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