Triethylamine → HCID 53680058, compound

HRID 1598557Notes

Reaction equation

HRID 1598557 reaction equation
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.C(N(CC)CC)C.[CH2:18]([S:22](Cl)(=[O:24])=[O:23])[CH2:19][CH2:20][CH3:21]>C(Cl)Cl>[CH2:18]([S:22]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)(=[O:24])=[O:23])[CH2:19][CH2:20][CH3:21]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 754301-Butanesulfonyl chlorideHCID 763102-Aminoindane

Product 1

HCID 53680058HCID 53680058, compoundYield 90.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 87.44 g of 2-aminoindane dissolved in 800 ml of methylene chloride was added 66.43 g of triethylamine, and 102.8 g of n-butylsulfonyl chloride was added dropwise thereto under ice cooling. The mixture was stirred at the same temperature for 1 hour. The reaction mixture was washed with diluted hydrochloric acid and dried, and then the solvent was removed. The resulting crystals were recrystallized from isopropyl ether to obtain 151.12 g of 2-n-butylsulfonylaminoindane.

Workup

  1. additionwas added dropwise
  2. washThe reaction mixture was washed with diluted hydrochloric acid
  3. customdried
  4. customthe solvent was removed
  5. customThe resulting crystals were recrystallized from isopropyl ether

Sources & evidence

ORD record
ord-2b7a5b893d784234846f47ad3d1ac579
Source dataset
uspto-grants-1998_04
Patent number
US05739132

Reaction notes

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