Sodium Hydroxide → HCID 18929730, compound

HRID 1598571Notes

Reaction equation

HRID 1598571 reaction equation
[OH-].[Na+].[CH2:3]([S:7]([NH:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]3[CH:21]=[CH:22][C:23](=[O:32])[N:24]([CH2:26][C:27]([O:29]CC)=[O:28])[N:25]=3)[CH:17]=2)[CH2:12]1)(=[O:9])=[O:8])[CH2:4][CH2:5][CH3:6]>CO>[CH2:3]([S:7]([NH:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]3[CH:21]=[CH:22][C:23](=[O:32])[N:24]([CH2:26][C:27]([OH:29])=[O:28])[N:25]=3)[CH:17]=2)[CH2:12]1)(=[O:8])=[O:9])[CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18929818HCID 18929818, compound

Product 1

HCID 18929730HCID 18929730, compoundYield 82.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

11.3 ml of a 1N sodium hydroxide aqueous solution was added dropwise under ice cooling to 3.25 g of 2-n-butylsulfonylamino-5-[2-ethoxycarbonylmethylpyridazin-3(2H)-on-6-yl]indane suspended in 50 ml of methanol, and the mixture was stirred at room temperature for 5 hours. Methanol was removed, water was added to the residue, and the mixture was made acidic with 10% hydrochloric acid. Crystals precipitated were collected by filtration, washed with water and then recrystallized from ethanol-water to obtain 2.50 g of 2-n-butylsulfonylamino-5-[2-carboxymethylpyridazin-3(2H)-on-6-yl]indane.

Workup

  1. customMethanol was removed
  2. additionwater was added to the residue
  3. customCrystals precipitated
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customrecrystallized from ethanol-water

Sources & evidence

ORD record
ord-5d16bab03990474e91b1264d07ee5c73
Source dataset
uspto-grants-1998_04
Patent number
US05739132

Reaction notes

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