Sodium Hydroxide → HCID 18929730, compound

Participants

Reaction Steps

11.3 ml of a 1N sodium hydroxide aqueous solution was added dropwise under ice cooling to 3.25 g of 2-n-butylsulfonylamino-5-[2-ethoxycarbonylmethylpyridazin-3(2H)-on-6-yl]indane suspended in 50 ml of methanol, and the mixture was stirred at room temperature for 5 hours. Methanol was removed, water was added to the residue, and the mixture was made acidic with 10% hydrochloric acid. Crystals precipitated were collected by filtration, washed with water and then recrystallized from ethanol-water to obtain 2.50 g of 2-n-butylsulfonylamino-5-[2-carboxymethylpyridazin-3(2H)-on-6-yl]indane.

Provenance & Evidence