反应详情

温度

90 °C

A mixture of 5,8-dimethyl-6-nitro-4-quinolone (7.12 g, 32.7 mmol), phosphorus oxybromide (7.47 g, 26.12 mmol), pyridine (5.3 mL), and toluene (90 mL) is heated at 90° C. for 6 hours. The mixture is filtered hot, and the solid is washed with water and methylene chloride. The filtrate is extracted with methylene chloride (3×100 mL), and the combined organic layers are dried (sodium sulfate) and evaporated to afford 4-bromo-5,8-dimethyl-6-nitroquinoline.

1. filtrationThe mixture is filtered hot
2. washthe solid is washed with water and methylene chloride
3. extractionThe filtrate is extracted with methylene chloride (3×100 mL)
4. dry with materialthe combined organic layers are dried (sodium sulfate)
5. customevaporated