4-[(Benzo[b]thiophene-3-yl)carbonyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester → (Benzo[b]thiophene-3-yl)(4-piperidinyl)methanone

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Reaction Steps

Dissolve 4-[(benzo[b]thiophene-3-yl)carbonyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (3.75 g, 10.8 mmol) in trifluoroacetic acid (30 mL). Stir at room temperature for 30-40 minutes. Cool in an ice bath and dilute with ethyl ether (200 mL). Keep at 0° C. for 1-2 hours, collect the solid by filtration and recrystallize (methanol/ethyl ether) to give the title compound as small colorless plates; mp 195°-197° C.

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