反应详情

Dissolve 4-[(benzo[b]thiophene-3-yl)carbonyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (3.75 g, 10.8 mmol) in trifluoroacetic acid (30 mL). Stir at room temperature for 30-40 minutes. Cool in an ice bath and dilute with ethyl ether (200 mL). Keep at 0° C. for 1-2 hours, collect the solid by filtration and recrystallize (methanol/ethyl ether) to give the title compound as small colorless plates; mp 195°-197° C.

1. temperatureCool in an ice bath
2. waitKeep at 0° C. for 1-2 hours
3. customcollect the solid
4. filtrationby filtration
5. customrecrystallize (methanol/ethyl ether)