反应详情

A mixture of tert-butyl 2,4-dioxo-3-methyl-1,3,8-triaza-8-spiro[4.5]decanecarboxylate (4.7 g, 16.6 mmol), hydrogen chloride (5 g, 13.7 mmol) and ethanol (90 mL) was heated approximately 10 minutes at reflux. The mixture was cooled in an ice-bath and the solids were collected, washed with ethanol and dried at 70° C. to give 3-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride (3.5 g, 15.9 mmol).

1. temperaturewas heated approximately 10 minutes
2. temperatureat reflux
3. temperatureThe mixture was cooled in an ice-bath
4. customthe solids were collected
5. washwashed with ethanol
6. customdried at 70° C.