Hydrochloric Acid → HCID 18931201, compound

Participants

Reaction Steps

A mixture of 8-[5,5-ethylenedioxy-5-(5-chloro-2-methoxyphenyl)pentyl]-1,3,8-triaza-spiro[4.5]decane-2,4-dione (1-1.1 g, 2.3-2.6 mmol), prepared as in Example 23, 10% hydrochloric acid (approximately 1 mL) and methanol (approximately 30 mL) was heated to a boil and then allowed to cool and stand approximately 4 hour at 25° C. The solids were collected and dried under vacuum at 70° C. to give 8-[5-(5-chloro-2-methoxyphenyl)-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride (0.37 g, 0.57 mmol), m.p. 260°-262° C.

Provenance & Evidence