Hydrochloric Acid → HCID 18931201, compound

HRID 1599008Notes

Reaction equation

HRID 1599008 reaction equation
C1CO[C:3]([C:20]2[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:21]=2[O:27][CH3:28])([CH2:4][CH2:5][CH2:6][CH2:7][N:8]2[CH2:19][CH2:18][C:11]3([NH:15][C:14](=[O:16])[NH:13][C:12]3=[O:17])[CH2:10][CH2:9]2)[O:2]1.Cl>CO>[ClH:26].[Cl:26][C:24]1[CH:23]=[CH:22][C:21]([O:27][CH3:28])=[C:20]([C:3](=[O:2])[CH2:4][CH2:5][CH2:6][CH2:7][N:8]2[CH2:19][CH2:18][C:11]3([NH:15][C:14](=[O:16])[NH:13][C:12]3=[O:17])[CH2:10][CH2:9]2)[CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18931188HCID 18931188, compound

Product 1

HCID 18931201HCID 18931201, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 8-[5,5-ethylenedioxy-5-(5-chloro-2-methoxyphenyl)pentyl]-1,3,8-triaza-spiro[4.5]decane-2,4-dione (1-1.1 g, 2.3-2.6 mmol), prepared as in Example 23, 10% hydrochloric acid (approximately 1 mL) and methanol (approximately 30 mL) was heated to a boil and then allowed to cool and stand approximately 4 hour at 25° C. The solids were collected and dried under vacuum at 70° C. to give 8-[5-(5-chloro-2-methoxyphenyl)-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride (0.37 g, 0.57 mmol), m.p. 260°-262° C.

Workup

  1. temperaturewas heated to a boil
  2. temperatureto cool
  3. customThe solids were collected
  4. customdried under vacuum at 70° C.

Sources & evidence

ORD record
ord-cedc0bb46e484118870bfd076512c61c
Source dataset
uspto-grants-1998_04
Patent number
US05739336

Reaction notes

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