Dabco → HCID 18931469, compound

HRID 1599011Notes

Reaction equation

HRID 1599011 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:3][CH2:2]1.C1[N:26]2[CH2:27][CH2:28]N([CH2:24][CH2:25]2)C1>>[CH:24]12[CH2:25][N:26]([C:11]3[C:12]([F:14])=[C:13]4[C:8]([C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5][N:4]4[CH:1]4[CH2:3][CH2:2]4)=[CH:9][C:10]=3[F:16])[CH2:27][CH:28]1[CH2:8][CH2:7][CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 9237DabcoHCID 5354141-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 18931469HCID 18931469, compoundYield 240%

Procedure

Heat 1.4 g (5 mmol) of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 0.6 g (5 mmol) of DABCO and 0.8 g (6 mmol) of the title compound from Example A to reflux for 3 h in a mixture consisting of 15 ml of acetonitrile and 7.5 ml of DMF. After cooling, add 25 ml of water and 2.5 ml of acetic acid, and filter off the precipitate with suction, wash it with water, and dry it at 50° C.

Sources & evidence

ORD record
ord-2b0b855b9f9d4086ac06af8a89a21585
Source dataset
uspto-grants-1998_04
Patent number
US05739339

Reaction notes

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