反应详情

A mixture of N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide (500 mg), ethanolamine (172 mg) and dimethylacetamide (4 ml) is heated with stirring at 110°-120° C. for 20 hours. After cooling, to the mixture is added an aqueous ammonium chloride solution, and the mixture is extracted with ethyl acetate. The extract is washed with water, dried, and evaporated under reduced pressure to remove the solvent. The residue is purified by silica gel column chromatography (solvent; chloroform:ethyl acetate=3:1) to give the title compound (57 mg) as a powder.

1. temperatureis heated
2. temperatureAfter cooling, to the mixture
3. extractionthe mixture is extracted with ethyl acetate
4. washThe extract is washed with water
5. customdried
6. customevaporated under reduced pressure
7. customto remove the solvent
8. customThe residue is purified by silica gel column chromatography (solvent; chloroform:ethyl acetate=3:1)