反应详情

A mixture of 4-amino-6-chloro-5-(4-methylphenyl)pyrimidine (500 mg), ethylene glycol (10 ml) and sodium hydride (60% dispersion, 0.46 g) is reacted at 70° C. for two hours, and then reacted at 90° C. for five hours. The reaction mixture is treated with a saturated ammonium chloride solution, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated under reduced pressure to remove the solvent. The residue is crystallized from hexane-ethyl acetate to give 2-{6-amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol (422 mg).

1. customis reacted at 70° C. for two hours
2. customreacted at 90° C. for five hours
3. extractionextracted with ethyl acetate
4. washThe ethyl acetate layer is washed
5. customdried
6. customevaporated under reduced pressure
7. customto remove the solvent
8. customThe residue is crystallized from hexane-ethyl acetate