HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67661848, compound → HCID 67660614, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67661848 | HCID 67661848 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 67660614 | HCID 67660614 | 56% |
Reaction Steps
(3aS,4S,6S,7aR)-6-Cyanomethyl-2-[(2-hydroxyphenyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol is obtained by proceeding as described in Example 4, from 1.3 g of (3aS,4S,6S,7aR)-6-cyanomethyl-2-[(2-benzyloxyphenyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol, 130 cm3 of ethanol, 0.3 g of 20% palladium hydroxide on carbon black, and hydrogen. Purification by chromatography gives 0.60 g of (3aS,4S,6S,7aR)-6-cyanomethyl-2-[(2-hydroxyphenyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol in the form of a thick white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05739351 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-744aadd5b0ee4f4a99996f40723e082e |
| Source note | uspto-grants-1998_04 |