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HRID1599140

反应详情

EQUATION

反应方程式

HRID 1599140 的结构方程式

REACTANTS

反应物

2
反应SMILES：COc1ccccc1[C@]1(O)C[C@H](CC#N)C[C@H]2CN(C(=O)Cc3ccccc3OCc3ccccc3)C[C@H]21
HCID67661848

未命名化合物

反应SMILES：[H][H]
HCID178418361

未命名化合物

PRODUCTS

产物

1
反应SMILES：COc1ccccc1[C@]1(O)C[C@H](CC#N)C[C@H]2CN(C(=O)Cc3ccccc3O)C[C@H]21
HCID67660614

未命名化合物

收率 56%

AUXILIARIES

试剂、催化剂与溶剂

2
反应SMILES：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

反应SMILES：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

(3aS,4S,6S,7aR)-6-Cyanomethyl-2-[(2-hydroxyphenyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol is obtained by proceeding as described in Example 4, from 1.3 g of (3aS,4S,6S,7aR)-6-cyanomethyl-2-[(2-benzyloxyphenyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol, 130 cm3 of ethanol, 0.3 g of 20% palladium hydroxide on carbon black, and hydrogen. Purification by chromatography gives 0.60 g of (3aS,4S,6S,7aR)-6-cyanomethyl-2-[(2-hydroxyphenyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol in the form of a thick white foam.

WORKUP

后处理

  1. customPurification by chromatography