Hydrochloric Acid → 2-Amino-5-bromo-3-iodobenzenesulphonic acid

HRID 1599169Notes

Reaction equation

HRID 1599169 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[S:9]([OH:12])(=[O:11])=[O:10].[I:13]Cl.Cl>CO>[NH2:1][C:2]1[C:7]([I:13])=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[S:9]([OH:12])(=[O:11])=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24640Iodine chlorideHCID 150236152-Amino-5-bromobenzenesulphonic acid

Product 1

HCID 189193852-Amino-5-bromo-3-iodobenzenesulphonic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
90 °C

Procedure

To 45 g (176 mmol) of 2-amino-5-bromobenzenesulphonic acid are added 46 g (282 mmol) of iodine chloride, 400 ml of aqueous 1N hydrochloric acid solution and 400 ml of methanol. The mixture is heated at 90° C. for 18 hours and concentrated under reduced pressure, and the residue is crystallized from ethanol.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customthe residue is crystallized from ethanol

Sources & evidence

ORD record
ord-45bc956c4420476587d1ebfe4ddc1357
Source dataset
uspto-grants-1998_04
Patent number
US05739382

Reaction notes

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