Hydrochloric Acid → 2,4,5-Trifluoro-3-hydroxybenzoic Acid
Reaction equation
[OH:1][C:2]1[C:3]([F:16])=[C:4]([C:13]([OH:15])=[O:14])[C:5](=[C:9]([F:12])[C:10]=1[F:11])C(O)=O.Cl>>[OH:1][C:2]1[C:3]([F:16])=[C:4]([CH:5]=[C:9]([F:12])[C:10]=1[F:11])[C:13]([OH:15])=[O:14]Participants
3
Procedure
The procedure as described in Example 1 is followed, but only 9 g of a mixture of various aliphatic trialkylamines each having 6 to 14 carbon atoms in the alkyl radical (Hostarex A 327; a commercial product of Hoechst AG) and 518 g of an aqueous solution which contains 29.8 g (0.126 mol) of 4-hydroxy-3,5,6-trifluorophthalic acid in the form of corresponding alkali metal salts are used and, with addition of in total 158.3 g of 30% strength aqueous hydrochloric acid, likewise in 6 hours, 23.25 g (95.9% of theory) of 3-hydroxy-2,4,5-trifluorobenzoic acid are obtained.
Sources & evidence
- ORD record
- ord-8873ec0b6e024b12966af5ee90ad6245
- Source dataset
- uspto-grants-1998_04
- Patent number
- US05739388
Reaction notes
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