反应详情

Methyl (4S, 5R)-5-(3,4-dibenzyloxyphenyl)-2-phenyl-2-oxazoline-4-carboxylate (157 mg, 0.50 mmol), was added to 1N-hydrochloric acid (5 ml) with stirring, and the mixture was refluxed for 17 hours. After cooling to room temperature, the reaction mixture was washed with ether and neutralized with 1N sodium hydroxide to obtain precipitated crystals. The precipitated crystal then was filtered to obtain 76 mg (0.36 mmol, yield: 71%) of L-threo DOPS.

1. temperaturethe mixture was refluxed for 17 hours
2. washthe reaction mixture was washed with ether and neutralized with 1N sodium hydroxide
3. customto obtain
4. customprecipitated crystals
5. filtrationThe precipitated crystal then was filtered