Formamide → HCID 18374041, compound

HRID 1599215Notes

Reaction equation

HRID 1599215 reaction equation
[CH:1]([NH2:3])=[O:2].[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1>C(O)=O>[CH:1]([NH:3][CH:11]([C:8]1[CH:9]=[CH:10][C:5]([Cl:4])=[CH:6][CH:7]=1)[CH3:12])=[O:2]

Participants

4

Reactant 2

HCID 713Formamide2×HCID 7467P-Chloroacetophenone2×

Product 1

HCID 18374041HCID 18374041, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent2×

Procedure

In the same manner as in Example 3 except that a mixture of formamide, formic acid and 4'-chloroacetophenone was heated with stirring at 160° C. for 6 hours in place of the concurrent addition of 4'-chloroacetophenone and formic acid to formamide for 3 hours and keeping the mass after the addition stirred for 3 hours, the reaction and post treatment were carried out to obtain 144.2 g of crude N-formyl-1-(4-chlorophenyl)ethylamine; the purity: 84.6%.

Workup

  1. temperaturewas heated
  2. additionafter the addition
  3. customthe reaction and post treatment

Sources & evidence

ORD record
ord-d8207980c6c643fb96dc9e37e66190b8
Source dataset
uspto-grants-1998_04
Patent number
US05739401

Reaction notes

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