Glycolic Acid → HCID 178519935, compound

HRID 1599299Notes

Reaction equation

HRID 1599299 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[C:10](O)(=O)[CH2:11][OH:12]>>[Cl:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:10]([CH2:11][OH:12])[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 757Glycolic AcidHCID 12682545-Chloropyridine-2,3-diamine

Product 1

HCID 178519935HCID 178519935, compound

Procedure

A procedure similar to that described in Preparation 43 was repeated, except that 7.67 g of 5-chloro-2,3-diaminopyridine (prepared as described in Preparation 62) and 18.6 g of glycolic acid were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 8.83 g of the title compound, melting at 209°-211° C.

Workup

  1. customA procedure similar to that described in Preparation 43

Sources & evidence

ORD record
ord-241b6f1ffa904b4bb8185221771a7613
Source dataset
uspto-grants-1998_04
Patent number
US05739345

Reaction notes

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