HCID 18928128, compound → 1-Bromomethyl-2-carboxy-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one

HRID 1599413Notes

Reaction equation

[Br:1][CH2:2][C:3]1[N:7]2[C:8]3[C:13]([NH:14][C:15](=[O:16])[C:6]2=[N:5][C:4]=1[C:21]([O:23]CC)=[O:22])=[CH:12][C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=3>Br>[Br:1][CH2:2][C:3]1[N:7]2[C:8]3[C:13]([NH:14][C:15](=[O:16])[C:6]2=[N:5][C:4]=1[C:21]([OH:23])=[O:22])=[CH:12][C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=3

Participants

Conditions

Temperature: 80 °C

Procedure

A suspension of 1-bromomethyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4-(5H)-one (Example 3) (500 mg, 1.2 mmol) in hydrobromic acid (48% in water) (25 ml) was stirred at 80° C. for 16 h. The mixture was concentrated in vacuo, and the residue stirred with water to give 340 mg (73%) of the title compound, which was isolated by filtration. M.p. >250° C.

Workup

concentrationThe mixture was concentrated in vacuo
stirringthe residue stirred with water

Sources & evidence

ORD record: ord-dff19a3044164c698ee845ed24987fca
Source dataset: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05741785

Reaction notes

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