反应详情

温度

80 °C

A suspension of 1-bromomethyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4-(5H)-one (Example 3) (500 mg, 1.2 mmol) in hydrobromic acid (48% in water) (25 ml) was stirred at 80° C. for 16 h. The mixture was concentrated in vacuo, and the residue stirred with water to give 340 mg (73%) of the title compound, which was isolated by filtration. M.p. >250° C.

1. concentrationThe mixture was concentrated in vacuo
2. stirringthe residue stirred with water