HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1599417Generated: November 2, 2026
2-Ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one → 2-Carboxy-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo [1,2-a]quinoxalin-4(5H)-one
https://huagongshe.com/reaction/1599417
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one | HCID 18928138 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 2-Carboxy-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo [1,2-a]quinoxalin-4(5H)-one | HCID 18928122 | — |
Reaction Steps
A suspension of 2-ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 7) (300 mg, 0.72 mmol) in hydrobromic acid (48% in water) (20 ml) was stirred at 80° C. for 16 h. The precipitate was collected and washed with ether. M.p. >250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05741785 |
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| Source dataset | uspto-grants-1998_04 |
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| ORD ID | ord-60f78826e80e43b5b85791ad9afe7c4e |
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| Source note | uspto-grants-1998_04 |
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