2-Ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one → 2-Carboxy-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo [1,2-a]quinoxalin-4(5H)-one

HRID 1599417Notes

Reaction equation

C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][N:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH3:30])=[O:5])C>Br>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:21])([F:20])[F:22])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][N:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH3:30])([OH:5])=[O:3]

Participants

Conditions

Temperature: 80 °C

Procedure

A suspension of 2-ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 7) (300 mg, 0.72 mmol) in hydrobromic acid (48% in water) (20 ml) was stirred at 80° C. for 16 h. The precipitate was collected and washed with ether. M.p. >250° C.

Workup

customThe precipitate was collected
washwashed with ether

Sources & evidence

ORD record: ord-60f78826e80e43b5b85791ad9afe7c4e
Source dataset: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05741785

Reaction notes

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