1-(4,5-Dichloro-1-imidazolyl)methyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one → HCID 18928131, compound

HRID 1599419Notes

Reaction equation

HRID 1599419 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][N:5]([CH2:8][C:9]2[N:13]3[C:14]4[C:19]([NH:20][C:21](=[O:22])[C:12]3=[N:11][C:10]=2[C:27]([O:29]CC)=[O:28])=[CH:18][C:17]([C:23]([F:26])([F:25])[F:24])=[CH:16][CH:15]=4)[C:6]=1[Cl:7]>Br>[C:27]([C:10]1[N:11]=[C:12]2[C:21](=[O:22])[NH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:23]([F:25])([F:26])[F:24])[CH:18]=3)[N:13]2[C:9]=1[CH2:8][N:5]1[C:6]([Cl:7])=[C:2]([Cl:1])[N:3]=[CH:4]1)([OH:29])=[O:28]

Participants

3

Reactant 1

HCID 189281261-(4,5-Dichloro-1-imidazolyl)methyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one

Product 1

HCID 18928131HCID 18928131, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A suspendion of 1-(4,5-dichloro-1-imidazolyl)methyl-2-ethoxycarbonyl-7trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 9) (120 mg, 0.25 mmol) in hydrobromic acid (48% in water) (10 ml) was stirred at 80° C. for 6 h. The mixture was concentrated in vacuo and the residue added acetone. The title compound was isolated by filtration to yield 80 mg (61%) as a hydrobromic salt. M.p. 213°-215° C.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. additionthe residue added acetone

Sources & evidence

ORD record
ord-91f0e3032ff3418b814d935c055775d4
Source dataset
uspto-grants-1998_04
Patent number
US05741785

Reaction notes

Loading…