1-Methylpiperazine → HCID 18928141, compound

HRID 1599420Notes

Reaction equation

HRID 1599420 reaction equation
Br[CH2:2][C:3]1[N:7]2[C:8]3[C:13]([NH:14][C:15](=[O:16])[C:6]2=[N:5][C:4]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:12][C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=3.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>C(#N)C>[CH2:24]([O:23][C:21]([C:4]1[N:5]=[C:6]2[C:15](=[O:16])[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[C:11]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)[N:7]2[C:3]=1[CH2:2][N:30]1[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]1)=[O:22])[CH3:25]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 18928128HCID 18928128, compound

Product 1

HCID 18928141HCID 18928141, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 1-bromomethyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 3) (630 mg, 1.5 mmol) in acetonitrile (180 ml) was added N-methylpiperazine (200 mg, 2.0 mmol). Stirring of the mixture was continued overnight at 25° C. followed by evaporation in vacuo. The residue was submitted to flash chromatography on silica gel 60 eluting with dichloromethane/methanol/ammonium hydroxide (90:10:0.5) to give 450 mg (69%) of the title compound. M.p. 255° C.

Workup

  1. customfollowed by evaporation in vacuo

Sources & evidence

ORD record
ord-29925840714141e9b97b0a10e605d0b2
Source dataset
uspto-grants-1998_04
Patent number
US05741785

Reaction notes

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