Hydrochloric Acid → HCID 18928130, compound

HRID 1599424Notes

Reaction equation

HRID 1599424 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([S:19]([CH3:22])(=[O:21])=[O:20])[CH:14]=3)[N:9]2[C:23]=1[CH3:24])=[O:5])C.O.Cl>[OH-].[K+]>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([S:19]([CH3:22])(=[O:20])=[O:21])[CH:14]=3)[N:9]2[C:23]=1[CH3:24])([OH:5])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 18928118HCID 18928118, compound

Product 1

HCID 18928130HCID 18928130, compoundYield 25.3%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Conditions

Temperature
80 °C

Procedure

A suspension of 2-ethoxycarbonyl-1-methyl-7-methylsulfonylimidazo[1,2-a]quinoxalin-4(5H)-one (430 mg, 1.23 mmol) in 2M potassium hydroxide (15 ml) was stirred at 80° C. for 6 h. The reaction mixture was added water (10 ml) and pH adjusted to pH 7 with 1N hydrochloride acid. The precipitate was filtered off and washed with water to give 100 mg (25%) of the title compound as the potassium salt. M.p. 228° C.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-4af61e0844aa4d809ff1fd6a42be0b0f
Source dataset
uspto-grants-1998_04
Patent number
US05741785

Reaction notes

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