Hydrazine hydrate (1:1) → HCID 18928120, compound

HRID 1599425Notes

Reaction equation

C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][C:25]1[NH:26][CH:27]=[CH:28][N:29]=1)=O)C.O.[NH2:31][NH2:32]>CO>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:20])[F:21])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][C:25]1[NH:26][CH:27]=[CH:28][N:29]=1)(=[O:3])[NH:31][NH2:32]

Participants

Conditions

Temperature: 60 °C

Procedure

A solution of 2-ethoxycarbonyl-1-(1-imidazolylmethyl)-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 5) (1.0 g, 2.5 mmol) in methanol (50 ml) was added hydrazine hydrate (500 μl, 10.3 mmol) in methanol (20 ml). The reaction mixture was stirred at 60° C. for 16 h and then concentrated in vacuo. The residue was added ether and the solid isolated by filtration to yield 860 mg (88%) of the title compound. M.p. >250° C.

Workup

concentrationconcentrated in vacuo
additionThe residue was added ether
customthe solid isolated by filtration

Sources & evidence

ORD record: ord-c1b12545179d470aaa56817cc152ec9e
Source dataset: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05741785

Reaction notes

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