Hydrochloric Acid → HCID 70300633, compound

HRID 1599456Notes

Reaction equation

HRID 1599456 reaction equation
C[O:2][C:3](=[O:28])[CH2:4][CH:5]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][N:13]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH2:17][CH2:16][C:15]3[CH:24]=[CH:25][CH:26]=[CH:27][C:14]2=3)[CH2:6]1.[OH-].[Na+].[ClH:31]>C(O)C>[ClH:31].[CH:24]1[C:15]2[CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[N:13]([CH2:12][CH2:11][CH2:10][N:7]3[CH2:8][CH2:9][CH:5]([CH2:4][C:3]([OH:28])=[O:2])[CH2:6]3)[C:14]=2[CH:27]=[CH:26][CH:25]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium Hydroxide2×HCID 536769941-(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-1-propyl)-3-pyrrolidinacetic acid methyl ester

Product 1

HCID 70300633HCID 70300633, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The above ester (0.85 g, 0.0022 mol) was dissolved in ethanol (6 ml) and 0.5N NaOH was added. By continued addition of 0.25N NaOH pH was kept at approximately 12 for 3 days. Dilute HCl (approx. 1N) was added until pH=7, and the solvent was evaporated in vacuo.

Workup

  1. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-1d5ba421bdbb40f3819bdb5592b8459a
Source dataset
uspto-grants-1998_04
Patent number
US05741791

Reaction notes

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