反应详情

After a mixture of n-pentadecanoic acid (25 g, 103 mmol) and thionyl chloride (3.15 g, 26.5 mmol) was stirred for 3 hours at 75° to 80° C., a solution of L-carnitine (4.27 g, 26.5 mmol) in 25 g of trichloroacetic acid was added at 60° C. The resulting mixture was stirred for 3 hours at 80° C. under argon atmosphere and then poured into stirred 100 ml of diethyl ether. The precipitates were collected by filtration, washed with diethyl ether and then dried to give 11.8 g of a crude desired product as a colorless solid. 11.8 g of the crude product was recrystallized from isopropanol to provide 9.38 g of (R)-(3-carboxy-2-pentadecanoyloxypropyl)trimethylammonium chloride as colorless needles.

1. stirringThe resulting mixture was stirred for 3 hours at 80° C. under argon atmosphere
2. additionpoured
3. filtrationThe precipitates were collected by filtration
4. washwashed with diethyl ether
5. customdried
6. customto give 11.8 g of a crude desired product as a colorless solid
7. custom11.8 g of the crude product was recrystallized from isopropanol