反应详情

The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 4-(3-methoxyphenyl)piperidine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 30% overall yield mp 121°-123°. FDMS m/e=381 (M+ of free base). α[D]589 =-12.69(c=0.53, methanol).

1. customoverall yield mp 121°-123°