Phthalimide → N-(3-Chloro-2-hydroxypropyl)-phthalimide

HRID 1599808Notes

Reaction equation

[CH2:1]([C@H:3]1[O:5][CH2:4]1)[Cl:2].[C:6]1(=[O:16])[NH:10][C:9](=[O:11])[C:8]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:7]12>>[Cl:2][CH2:1][CH:3]([OH:5])[CH2:4][N:10]1[C:9](=[O:11])[C:8]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:7]2[C:6]1=[O:16]

Participants

Reactant 2

HCID 6809Phthalimide

HCID 149428(+)-Epichlorohydrin

Product 1

HCID 262103N-(3-Chloro-2-hydroxypropyl)-phthalimide

Procedure

reacting (S)-(+)-epichlorohydrin with phthalimide to form a stereoisomer of 1-chloro-3-phthalimido-2-propanol;

Sources & evidence

ORD record: ord-f44f56a22b8b4068aaf58000109ee83d
Source dataset: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05741912

Reaction notes

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