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HRID1599921

反应详情

EQUATION

反应方程式

HRID 1599921 的结构方程式

REACTANTS

反应物

2
反应SMILES：Br
HCID260

Hydrogen Bromide

BrH

反应SMILES：CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(COCCNC(=O)OCc2ccccc2)cc1)NS(=O)(=O)c1ccccc1
HCID15850750

未命名化合物

PRODUCTS

产物

1
反应SMILES：NCCOCc1ccc(C(=O)NC[C@H](NS(=O)(=O)c2ccccc2)C(=O)O)cc1
HCID15850751

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Cbz-ester 15-4 (200 mg, 0.33 mmol) was treated with 4 mL 30% HBr in HOAc for 2 h then concentrated and purified by flash chromatography (silica, 50:1:1 EtOH/NH4OH/H2O) providing 15-5 as a white solid.

WORKUP

后处理

  1. concentrationthen concentrated
  2. custompurified by flash chromatography (silica, 50:1:1 EtOH/NH4OH/H2O)