Hydrochloric Acid → 4-[2-(Thiazol-2-ylamino)ethyloxy]benzoic acid hydrochloride

HRID 1599941Notes

Reaction equation

HRID 1599941 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][CH2:7][CH2:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][CH:11]=1.[ClH:20]>>[ClH:20].[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][CH2:7][CH2:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18928557Methyl 4-[2-(thiazol-2-ylamino)ethyloxy]benzoate

Product 1

HCID 867524494-[2-(Thiazol-2-ylamino)ethyloxy]benzoic acid hydrochloride

Procedure

Ester 24-4 (180 mg, 0.65 mmol) was heated at 50° in 6 mL 6 N HCl for 16 h, then concentrated providing 24-5 as a yellow solid.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-d438a0e7dfce452d857d5b046eab21aa
Source dataset
uspto-grants-1998_04
Patent number
US05741796

Reaction notes

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