Hydrochloric Acid → 6-Amino-2-methyl-3-nitrobenzoic acid
Reaction equation
[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([NH:14]C(=O)C)[C:3]=1[C:4]([OH:6])=[O:5].Cl>[OH-].[Na+]>[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([NH2:14])[C:3]=1[C:4]([OH:6])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 95 °C
Procedure
450 ml of 2N NaOH are initially taken and 75.6 g (0.317 mol) of 2-methyl-3-nitro-6-acetamidobenzoic acid are added. The reaction mixture is then warmed to 95° C. and is stirred at this temperature for onehour. After cooling to 10° C., it is acidified by addition of 425 mlof 2N HCl, and the precipitate which deposits is filtered off with suction,washed with water and dried under reduced pressure at 50° C. Yield: 50.7 g (0.258 mol)=82% of theory, m.p.: 183°-184° C.
Workup
- temperatureAfter cooling to 10° C.
- filtrationthe precipitate which deposits is filtered off with suction,washed with water
- customdried under reduced pressure at 50° C
Sources & evidence
- ORD record
- ord-dd7a6fcc98724309855ca64eb13d661b
- Source dataset
- uspto-grants-1998_04
- Patent number
- US05744425
Reaction notes
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