Trifluoroacetic acid → HCID 53728432, compound

HRID 1599989Notes

Reaction equation

HRID 1599989 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9](=[CH:17][C:18]1[CH:23]=[C:22]([C:24]2[C:28]([Cl:29])=[C:27]([O:30][CH:31]([F:33])[F:32])[N:26]([CH3:34])[N:25]=2)[C:21]([Cl:35])=[CH:20][C:19]=1[Cl:36])[C:10]([O:12]C(C)(C)C)=[O:11]>ClCCl>[Cl:8][C:9](=[CH:17][C:18]1[CH:23]=[C:22]([C:24]2[C:28]([Cl:29])=[C:27]([O:30][CH:31]([F:32])[F:33])[N:26]([CH3:34])[N:25]=2)[C:21]([Cl:35])=[CH:20][C:19]=1[Cl:36])[C:10]([OH:12])=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54262010HCID 54262010, compound

Product 1

HCID 53728432HCID 53728432, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

85 ml of trifluoroacetic acid were added dropwise to a solution of 34.4 g (70 mmol) of tert-butyl 2-chloro-3-(2,4-dichloro-5-(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)phenyl)-propenoate in 85 ml of dichloromethane. After 3 hours the mixture was concentrated. The residue was triturated with n-hexane, then filtered off and dried. Yield: 19.9 g.

Workup

  1. concentrationAfter 3 hours the mixture was concentrated
  2. customThe residue was triturated with n-hexane
  3. filtrationfiltered off
  4. customdried

Sources & evidence

ORD record
ord-72841efaacdd4b8e9933539ef64bdc07
Source dataset
uspto-grants-1998_04
Patent number
US05744426

Reaction notes

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