Pyridine → HCID 86752465, compound

HRID 1599992Notes

Reaction equation

HRID 1599992 reaction equation
N1C=CC=CC=1.[SH:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].[Cl:14][C:15](=[CH:19][C:20]1[CH:25]=[C:24]([C:26]2[C:30]([Cl:31])=[C:29]([O:32][CH:33]([F:35])[F:34])[N:28]([CH3:36])[N:27]=2)[C:23]([Cl:37])=[CH:22][C:21]=1[Cl:38])[C:16](Cl)=[O:17]>O1CCCC1>[Cl:14][C:15](=[CH:19][C:20]1[CH:25]=[C:24]([C:26]2[C:30]([Cl:31])=[C:29]([O:32][CH:33]([F:35])[F:34])[N:28]([CH3:36])[N:27]=2)[C:23]([Cl:37])=[CH:22][C:21]=1[Cl:38])[C:16]([S:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:17]

Participants

5

Reactant 3

HCID 1049PyridineHCID 12185Ethyl ThioglycolateHCID 53725594HCID 53725594, compound

Product 1

HCID 86752465HCID 86752465, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.95 g (7.3 mmol) of pyridine and 0.88 g (7.3 mmol) of ethyl mercaptoacetate were added to a solution of 3.3 g (6.7 mmol) of 2-chloro-3-(2,4-dichloro-5-{4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)phenyl)propenoyl chloride in 70 ml of tetrahydrofuran. The reaction mixture was stirred for 8 hours and then concentrated. The crude product was purified by chromatography on silica gel (eluent: hexane/ethyl acetate =1:1). Yield: 2.1 g.

Workup

  1. concentrationconcentrated
  2. customThe crude product was purified by chromatography on silica gel (eluent: hexane/ethyl acetate =1:1)

Sources & evidence

ORD record
ord-a88a23d3798d450cbbdc85f307a6c462
Source dataset
uspto-grants-1998_04
Patent number
US05744426

Reaction notes

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