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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1600000Generated: October 31, 2026

Acetic Acid → HCID 21699317, compound

https://huagongshe.com/reaction/1600000

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantPyrrolidineHCID 31268—
Reactant6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedioneHCID 73273—
SolventWaterHCID 962—
ProductHCID 21699317HCID 2169931729%

Reaction Steps

To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at roomtemperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of thetitle compound were obtained (yield: 29%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05744475
Source datasetuspto-grants-1998_04
ORD IDord-19aac24d471c4036b4057885db42f119
Source noteuspto-grants-1998_04