Acetic Acid → HCID 21699317, compound

HRID 1600000Notes

Reaction equation

HRID 1600000 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:7][C:8]1[NH:13][C:12](=[O:14])[NH:11][C:10](=[O:15])[CH:9]=1.C(O)(=O)C>O>[N:1]1([CH2:7][C:8]2[NH:13][C:12](=[O:14])[NH:11][C:10](=[O:15])[CH:9]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 31268PyrrolidineHCID 732736-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 21699317HCID 21699317, compoundYield 29%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at roomtemperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of thetitle compound were obtained (yield: 29%).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customThe residue so obtained
  3. washwas washed with methanol
  4. filtrationfiltered

Sources & evidence

ORD record
ord-19aac24d471c4036b4057885db42f119
Source dataset
uspto-grants-1998_04
Patent number
US05744475

Reaction notes

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