反应详情

2,3-Epoxypropylbenzene (60 g, 448 mmol) and potassium cyanate (70 g, 364 mmol) were refluxed in DMF (600 ml) and water (300 ml) for 4 hours. The solvent was evaporated in vacuo and water added. The aqueous was then extracted with ethyl acetate, dried (Mg SO4) and evaporated. Recrystallization from ethyl acetate gave the product (28.2 g, 36%) Mpt 106°-107° C. MS (EI) 177 (M+), 133, 86.

1. customThe solvent was evaporated in vacuo and water
2. additionadded
3. extractionThe aqueous was then extracted with ethyl acetate
4. dry with materialdried (Mg SO4)
5. customevaporated
6. customRecrystallization from ethyl acetate