反应详情

7-Chloro-4-hydroxy-2-(4-methoxy-2-methylphenyl)-1,2,5,10-tetrahydropyridazino-[4,5-b]quinoline-1,10-dione (0.45 g, 1.17 mM) was stirred in methanol (20 mL) and N-Methyl-D-Glucamine (0.23 g, 1.17 mM) was added to give a clear yellow solution. This solution was concentrated and the residue was dissolved in water (20 mL) to give a yellow solution. This solution was filtered through a Gellman 0.45 um Acrodisc and concentrated to give a yellow residue. The residue was triturated with 2-propanol (20 mL) to givea yellow suspension. The solids were collected and washed with 2-propanol to give the title compound (0.20 g, 29%) as a yellow powder, mp=177° C. (decomp.).

1. customto give a clear yellow solution
2. concentrationThis solution was concentrated
3. dissolutionthe residue was dissolved in water (20 mL)
4. customto give a yellow solution
5. filtrationThis solution was filtered through a Gellman 0.45 um Acrodisc
6. concentrationconcentrated
7. customto give a yellow residue
8. customThe residue was triturated with 2-propanol (20 mL)
9. customThe solids were collected
10. washwashed with 2-propanol