Hydrochloric Acid → HCID 19365572, compound

HRID 1600067Notes

Reaction equation

HRID 1600067 reaction equation
[C:1]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[S:36][C:16]3[N:17]([CH2:27][C:28]4[C:33]([F:34])=[CH:32][CH:31]=[CH:30][C:29]=4[F:35])[CH:18]=[C:19]([S:22]([CH:24]([CH3:26])[CH3:25])=[O:23])[C:20](=[O:21])[C:15]=3[C:14]=2[CH2:37][N:38]([CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[CH3:39])=[CH:9][CH:8]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].[ClH:47].CCOCC>ClCCl>[ClH:47].[C:1]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[S:36][C:16]3[N:17]([CH2:27][C:28]4[C:33]([F:34])=[CH:32][CH:31]=[CH:30][C:29]=4[F:35])[CH:18]=[C:19]([S:22]([CH:24]([CH3:26])[CH3:25])=[O:23])[C:20](=[O:21])[C:15]=3[C:14]=2[CH2:37][N:38]([CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[CH3:39])=[CH:11][CH:12]=1)(=[O:5])[CH:2]([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 18926386HCID 18926386, compound

Product 1

HCID 19365572HCID 19365572, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (0.35 g, 0.53 mmol) obtained in Example 21 was dissolved in dichloromethane (5 ml). To the solution was added 1M hydrogen chloride in ether (1.06 ml, 1.06 mmol) under ice-cooling. The mixture was stirred for 30 minutes, the solvent was distilled off under reduced pressure. Thus obtained residue was recrystallized from dichloromethane-n-hexane to give pale yellow crystals (0.30 g, 77%).

Workup

  1. temperaturecooling
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThus obtained residue was recrystallized from dichloromethane-n-hexane

Sources & evidence

ORD record
ord-9868bc54e8dc4296ac37a4abbd74bc06
Source dataset
uspto-grants-1998_04
Patent number
US05744479

Reaction notes

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