Sodium methanolate methanol → 5-[(4-Fluorophenoxy)methyl]tetrahydro-3-furanthiol

HRID 1600097Notes

Reaction equation

HRID 1600097 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][CH2:7][C@@H:8]2[O:12][CH2:11][C@@H:10]([S:13]C(=O)C)[CH2:9]2)=[CH:4][CH:3]=1.C[O-].[Na+].CO>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH:8]2[O:12][CH2:11][CH:10]([SH:13])[CH2:9]2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 23694274Sodium methanolate methanolHCID 86750320Ethanethioic acid trans-(+/-)-S-[5-[(4-fluorophenoxy)methyl]tetrahydro-3-furanyl]ester

Product 1

HCID 189240045-[(4-Fluorophenoxy)methyl]tetrahydro-3-furanthiol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared by the procedure of Example 16 using 0.943 gof product from Example 35, 0.86 ml of 25% sodium methoxide/methyl alcohol and 12 ml of tetrahydrofuran to give 0.417 g of the desired product.

Sources & evidence

ORD record
ord-f6d2c29b97ab4b30b3c9d53ab61c79f1
Source dataset
uspto-grants-1998_04
Patent number
US05744465

Reaction notes

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