反应详情

To a 0° C. solution of 0.340 g of product from Example 321 in 4 ml of methylene chloride is added a solution of 1 ml of trifluoroacetic acid and 0.266 ml of water. The reaction is stirred at room temperature for 1 hour, concentrated in vacuo, extracted with methylene chloride, neutralized with 1 g of sodium bicarbonate, filtered and concentrated in vacuo to give after chromatography (Silica gel: 50-60% ethyl acetate/hexane) 0.222 g of the desired product.

1. concentrationconcentrated in vacuo
2. extractionextracted with methylene chloride
3. filtrationfiltered
4. concentrationconcentrated in vacuo